To explore prospective and current telehealth PrEP users’ experiences with quarterly laboratory monitoring and determine whether monitoring requirements were perceived as a barrier or benefit within a largely remote care model.

To explore cisgender women’s experiences with HIV prevention, knowledge and attitudes regarding pre-exposure prophylaxis, and anticipated barriers and facilitators to PrEP initiation and adherence before a demonstration project in Los Angeles and San Diego.

To explore adolescent and caregiver perspectives on sexual health and pre-exposure prophylaxis communication, including willingness to discuss PrEP and involve caregivers, in order to inform possible caregiver-focused interventions for adolescents in Alabama.

To evaluate the reach and adoption of distributing HIV self-test kits bundled with pre-exposure prophylaxis information through the friendship networks of PrEP clients in Miami and identify participant and network characteristics associated with kit distribution.

To explore Black adolescent girls’ and young women’s perspectives on barriers and opportunities related to sexual health care and PrEP prescribing in Alabama, including the influence of intersecting stigma and perceived relevance of PrEP.

To assess the acceptability and feasibility of delivering pre-exposure prophylaxis and medication for opioid use disorder through a mobile syringe services program among Black people who inject drugs in Miami-Dade County.

To characterize social determinants of health that impede HIV prevention and pre-exposure prophylaxis use among young men who have sex with men and transgender women in rural North and South Carolina, drawing on stakeholder interviews and community focus groups.

To understand patient and staff experiences with a Boston mobile clinic offering pre-exposure prophylaxis and sexual health services, focusing on perceived access, community, stigma, acceptability, feasibility, and recommended changes for improving longitudinal care.

To describe development and assess the feasibility of a community-based organization-linked telehealth pre-exposure prophylaxis program for Latinx sexual minority men, using referral, appointment, laboratory, prescribing, and time-to-care data from December 2020 through May 2023.

Not publicly retrievable

To assess Alabama clinic stakeholders’ perceptions of the acceptability, appropriateness, feasibility, usability, and sustainability of a prototype dashboard tracking the pre-exposure prophylaxis care continuum and identify modifications and implementation supports needed for continued use.

To evaluate uptake, time to initiation, prescription filling, and early clinical retention in a pharmacist-led same-day pre-exposure prophylaxis initiation program embedded within a nonclinical HIV testing center in Jackson, Mississippi.

To identify barriers and facilitators to PrEP use in Mississippi federally qualified health centers and develop acceptable, appropriate, tailored implementation strategies with PrEP-eligible patients and clinic staff using the i-PARIHS framework.

To assess Latina women’s perceptions of the acceptability and appropriateness of culturally tailored, women-centered information sessions delivered by a trusted community organization to increase knowledge and awareness of pre-exposure prophylaxis and telemedicine-based PrEP services.

To assess the acceptability and feasibility of remotely delivered pre-exposure prophylaxis care—including telemedicine, HIV self-testing, and mailed prescriptions—among PrEP-eligible adults recruited while receiving HIV testing through community organizations across Mississippi.

To assess the acceptability and preliminary effects of a one-hour provider training integrating PrEP clinical education with cultural competence compared with standard HIV continuing education in a pilot randomized trial.

To assess user characteristics, implementation barriers, feasibility, and acceptability of using the reSET-O mobile application to support pre-exposure prophylaxis and medication-assisted treatment adherence among women with opioid use disorder receiving community-based care in Philadelphia.

To evaluate quantitative and qualitative acceptability of dapivirine rectal gel delivered by an applicator or an artificial phallus among men who have sex with men participating in a randomized phase 1 trial.

To evaluate acceptability and side effects of a rectally administered dapivirine or placebo gel among HIV-negative adults from the United States and Thailand participating in a phase 1 trial of a potential short-acting HIV prevention product.

To assess quantitative and qualitative acceptability of three rectal dose volumes of PC-1005 multipurpose prevention gel among HIV-negative adults participating in a phase 1 trial at two United States sites.

To identify multilevel barriers and facilitators, assess acceptability and feasibility, and report six-month viral suppression from a pilot telehealth-enhanced harm-reduction model for rapidly initiating antiretroviral therapy among people who inject drugs.

To adapt and pilot a community-designed pre-exposure prophylaxis social-marketing campaign for Latino, Latina, and Latinx populations, particularly sexual minority men and transgender women, and evaluate its social-media reach, advertisement performance, and website use in Cook County, Illinois.

To qualitatively assess the organizational and positional barriers and facilitators affecting implementation of the University of Miami Mobile PrEP Program in Liberty City, as perceived by Mobile PrEP clients, community health organization representatives, and program staff in South Florida.

To describe early implementation of low-threshold pre-exposure prophylaxis services in three Philadelphia Department of Public Health-funded sexual health clinics and identify staff-recommended strategies and adaptations for delivering and scaling services that minimize barriers to entry and engagement.

To assess African American clergy members’ knowledge of Ending the HIV Epidemic and obtain their recommendations for faith-based contributions to HIV screening, care, PrEP promotion, and lessons transferable from the COVID-19 response.

To evaluate whether participation in nine culturally tailored HIV care interventions was associated with changes in care visits, antiretroviral therapy prescriptions, retention, and viral suppression among transgender women of color with HIV across nine United States organizations.

To develop and usability-test the iTransition mobile health intervention with youth and providers, then conduct a pilot implementation trial assessing feasibility, acceptability, use, and preliminary effects on adult-care linkage, retention, and viral suppression during transition from pediatric or adolescent HIV care.

To identify inner- and outer-setting barriers and facilitators that could influence adoption of trauma-informed care in a large urban HIV primary care center serving uninsured and underinsured patients in the southern United States.

To test conceptual pathways linking perceived stigma, attachment to the gay community, endorsement of negative pre-exposure prophylaxis stereotypes, and PrEP uptake among young men who have sex with men recruited online in the United States.

To compare discrimination experiences and hazardous alcohol use between sexual-minority and heterosexual adults with criminal legal involvement and examine associations between discrimination and hazardous drinking in baseline cohort data from the southern United States.

To evaluate the B-OK Bottles visual and tactile treatment-adherence tool among adults with HIV receiving case-management services in Philadelphia, examining changes in HIV treatment knowledge, attitudes, prevention beliefs, and intentions through surveys and qualitative interviews.

To identify barriers and facilitators affecting pre-exposure prophylaxis use and HIV testing among Latino sexual minority men and examine how their importance differed by age, immigration history, and type of prevention service.

To identify multilevel barriers and facilitators affecting preventive health care use among African-born people in King County, Washington, through interviews with community health event participants, medical professionals, and community leaders.

To identify barriers, facilitators, incremental staff time, and personnel costs associated with adding HIV testing, relinkage to HIV care, and pre-exposure prophylaxis referrals to sexually transmitted disease partner-services activities in Jackson, Mississippi.

To characterize PrEP knowledge, attitudes, prior experience, and preferences among HIV-negative cisgender women receiving care at a Chicago sexually transmitted infection clinic or emergency department using concurrent quantitative and qualitative methods.

To explore individual, social, and service-delivery factors influencing pre-exposure prophylaxis awareness and use among Haitian and Haitian American adults in Miami, Florida, in order to inform approaches for reducing disparities in PrEP uptake.

To explore how adult pre-exposure prophylaxis users recruited from a Boston community health center and an online social group perceived the relationship between PrEP use and their broader engagement with primary and preventive health care.

To assess longitudinal associations between self-reported alcohol, marijuana, popper, and stimulant use—including use before or during condomless anal intercourse—and initiation of and biologically measured adherence to pre-exposure prophylaxis among Black men who have sex with men in HPTN 073.

To examine how people with prior pre-exposure prophylaxis use changed or maintained PrEP use, sexual activity, and HIV and sexually transmitted infection prevention decisions during two periods of the COVID-19 pandemic at a Chicago health center.

To describe the prevalence, distance, and geographic patterns of residential mobility among people with HIV in Tennessee and estimate associations between moving in one year and subsequent retention in care, loss to follow-up, and viral suppression.

To identify clinic-level barriers and stakeholder-recommended strategies for engaging people with HIV who are out of care at a Ryan White-funded clinic in Atlanta, within planning for community-based care models.

To collaboratively identify, rate, and select acceptable, appropriate, and feasible strategies that community-based organizations and health centers could implement together to improve pre-exposure prophylaxis delivery for Latino men who have sex with men.

To characterize the communication appeals and message frames used in United States visual media campaigns intended to increase demand for HIV pre-exposure prophylaxis among cisgender and transgender women, using systematic content coding and thematic analysis.

To identify current practices and modifiable determinants of culturally responsive trauma-informed HIV care across Nashville institutions and collaboratively develop a network-wide implementation plan using process mapping, interviews, an implementation framework, and a community dissemination summit.

To understand factors shaping HIV-testing decisions among adult members of a Southern California American Indian community and identify culturally appropriate implementation strategies to increase the acceptability and adoption of HIV self-testing.

To compare the effectiveness and personnel-inclusive cost of routine screening, modified partner services, and a respondent-driven social-network strategy for identifying HIV-positive tests and new HIV diagnoses at a large academic medical center in Chicago.

To identify modifiable and systemic barriers to rapid antiretroviral therapy initiation by mapping the process from municipal HIV testing to treatment prescription and interviewing stakeholders at linked clinics in the Memphis metropolitan area.

To explore staff and patient perspectives on barriers, facilitators, and resource needs for implementing pre-exposure prophylaxis at federally qualified health centers in Mississippi, including the potential benefits and challenges of delivering PrEP services through telemedicine.

To conduct a secondary analysis of the myDEx randomized trial examining whether baseline sociodemographic characteristics and online partner-seeking behaviors among single young men who have sex with men were associated with log-ins, sessions viewed, and changes in HIV-related outcomes.

To use a bilingual, participatory innovation tournament to crowdsource, refine, and prioritize dissemination and implementation strategies for long-acting injectable cabotegravir pre-exposure prophylaxis among sexual minority men, particularly Black and Latino populations, in Chicago.

To evaluate the reach, acceptability, usability, patient-centeredness, and linkage outcomes of a culturally responsive social media outreach and peer navigation program connecting Latino gay and bisexual men in metropolitan Atlanta to HIV status-neutral prevention and care services.

To characterize changes from 2008 through 2020 and demographic disparities in new United States HIV diagnoses attributed to injection drug use, with attention to differences by sex and race or ethnicity among people who inject drugs.

To identify quantitative predictors of 24-week pre-exposure prophylaxis retention among transgender women and use in-depth interviews with PrEP-experienced transgender women to explain how sex work, drug use, housing, and gender-affirming care shaped retention.

To identify and prioritize barriers to rapid antiretroviral treatment initiation across HIV testing and Ryan White-funded treatment sites in Memphis, Tennessee, and to develop locally tailored implementation strategies compiled into a citywide rapid-treatment toolkit for future evaluation.

To identify culturally specific barriers and facilitators to pre-exposure prophylaxis uptake among Latino sexual minority men in Atlanta and use participant feedback to guide the functions and service criteria of the proposed SaludFindr HIV prevention application.

To use the Adaptome Model and input from PrEP-eligible young Black men who have sex with men and clinic staff in Mississippi to develop culturally and contextually adapted Acceptance and Commitment Therapy components for ACTPrEP.

To assess whether HIV status disclosure was associated with condomless insertive or receptive anal intercourse, including sex with partners of negative or unknown HIV status, among Black men with HIV in six United States cities.

To estimate associations between the transportation mode used to reach health care and persistence in pre-exposure prophylaxis care among urban gay, bisexual, and other men who have sex with men participating in the 2020 American Men’s Internet Survey.

To evaluate the acceptability and impact of electronically disseminating a web-based pre-exposure prophylaxis educational video on women’s PrEP knowledge, comfort discussing PrEP, contemplation, and subsequent initiation at two Planned Parenthood centers.

To determine whether access to an electronic patient portal was associated with retention in HIV care and annual viral suppression among people receiving care at a comprehensive HIV clinic in Nashville, Tennessee, from 2011 through 2016.

To assess the preliminary efficacy of an individualized planning and booster intervention embedded in partner and social-network services for improving three-month linkage to pre-exposure prophylaxis care, PrEP initiation, and time to linkage among Black men who have sex with men and Black transgender women.

To identify public health professionals’ barriers, facilitators, and strategies for implementing molecular HIV surveillance, developing real-time cluster detection and response interventions, and addressing stakeholder concerns in southern and midwestern United States settings.

To identify community-perceived barriers and facilitators to viral suppression in the Memphis Transitional Grant Area and opportunities for community health workers to strengthen outreach, engagement, and the local HIV care system.

To develop, implement, and evaluate the feasibility, acceptability, preliminary effects, and longer-term implementation readiness associated with a two-session HIV prevention and PrEP educational intervention for domestic violence advocates in Mississippi.

To compare the efficacy of a tailored web application combining HIV and sexually transmitted infection testing locators with personalized educational content versus a locator-only version for increasing routine testing among young men who have sex with men over 12 months.

To test whether Epic Allies, a gamified mobile application combining self-management tools and social support, improved viral suppression and antiretroviral adherence over 26 weeks among young men who have sex with men living with HIV.

To establish an academic-community partnership, assess barbers’ HIV knowledge and stigma, and explore the acceptability and potential design of barbershop-based strategies for HIV education, prevention, navigation, and stigma reduction for Black men in Nashville.

To examine patterns of physical and virtual sexual and drug-risk venue co-attendance among pre-exposure prophylaxis-eligible Latinx sexual minority men at different stages of PrEP use in South Florida and identify venues that might support targeted prevention delivery.

To explore awareness, acceptability, and early adoption of daily oral, long-acting injectable, and postrelease electronic-prescription PrEP among jail-involved Black sexual minority men and Black transgender women in Chicago and Baton Rouge.

To explore patient and primary care provider perceptions of the impact of Golden Compass, a multidisciplinary HIV-geriatrics program, on whole-person care, provider skills, functional health, and quality of life for adults aged 50 years or older.

To identify staff- and stakeholder-reported barriers and facilitators affecting equitable implementation of Philadelphia’s telehealth PrEP program for priority populations in routine service delivery using the Consolidated Framework for Implementation Research.

To explore structural, social, clinical, and behavioral factors contributing to lapses in pre-exposure prophylaxis care among men who have sex with men who had experienced interrupted PrEP use at clinics in the Midwest, South, and Northeast United States.

To assess whether comfort discussing sex with parents, family social support, disclosure of sexual identity to family, and prioritization of family were associated with current pre-exposure prophylaxis use among PrEP-indicated men who have sex with men aged 18–25 years.

To pilot the culturally specific Brothers Building Brothers by Breaking Barriers group program and assess its acceptability, satisfaction, safety, recruitment, and retention feasibility among young Black gay, bisexual, and other men who have sex with men living with HIV.

To determine the feasibility, acceptability, and early implementation of distributing HIV self-test kits and pre-exposure prophylaxis information through the social and sexual networks of Mobile PrEP clients in Miami-Dade County.

To evaluate the acceptability and feasibility of the Tasso OnDemand blood self-collection device for home-based pre-exposure prophylaxis monitoring and compare HIV, syphilis, and creatinine results from self-collected specimens with paired clinician-collected blood samples.

To pilot the Five Point Initiative, a community-informed bundled implementation strategy, and assess its reach, acceptability, feasibility, community partnerships, prevention activities, and HIV testing in heavily affected Black communities in Miami.

To compare depression response, remission, and symptom severity through 48 weeks among youth with HIV receiving a tailored, measurement-guided combination of cognitive behavioral therapy and medication management versus enhanced usual care at United States clinical research sites.

To characterize how HIV-related stigma and intersecting stigmas involving immigrant status, race or ethnicity, language, religion, and sexual norms influence HIV-testing behavior among Ethiopian, Somali, and Eritrean immigrant communities in King County, Washington.

To understand how internal medicine and infectious disease physicians chose between tenofovir disoproxil fumarate/emtricitabine and tenofovir alafenamide/emtricitabine for PrEP and identify influences on early adoption of the newer formulation during a period of changing options.

To quantify preferences for HIV care features and identify distinct preference patterns among people with HIV experiencing homelessness or unstable housing who used drop-in or traditional care in San Francisco during the COVID-19 pandemic.

To map multilevel HIV-related stigma-reduction activities used by New York City HIV service organizations, assess their evidence base, and characterize organizational and contextual barriers and facilitators as part of implementation planning for Ending the HIV Epidemic.

To compare oral, injectable, ring, and implant pre-exposure prophylaxis preferences and desired service-delivery, follow-up, marketing, and communication approaches among PrEP-inexperienced Black cisgender women aged 18–29 versus 30–44 in Baltimore, Maryland.

To quantify preferences for out-of-pocket cost, dispensing location, visit frequency, travel time, and integration with gender-affirming hormone care in hypothetical pre-exposure prophylaxis programs among sexually active HIV-negative transgender and gender-diverse adults in the United States.

To measure six-month PrEP persistence among Black cisgender women receiving PrEP at a Chicago federally qualified health center and examine demographic, clinical, and patient-reported factors associated with continued use during routine care.

To evaluate 12-month HIV viral suppression, care engagement, mortality, and participant characteristics associated with viral suppression among people with HIV, housing instability, and baseline viral nonsuppression enrolled in POP-UP, a low-barrier, drop-in HIV primary care model in San Francisco.

To assess delivery of HIV testing, pre-exposure prophylaxis, viral-load testing, and postdischarge linkage to HIV care among hospitalized patients with opioid use disorder and infectious complications of injection drug use across multiple United States medical centers.

To identify determinants of pre-exposure prophylaxis uptake among Black same gender-loving men in Mecklenburg County, North Carolina, and collaboratively develop client- and clinic-level implementation strategies and assess organizational readiness for future pilot testing.

To evaluate engagement and cost metrics for a multiplatform digital campaign promoting HIV and sexually transmitted infection services among gay, bisexual, and other men who have sex with men at an LGBTQ+ community health center in Rhode Island.

To conduct formative research with Black cisgender women in New Orleans and a community task force to identify locally relevant barriers to pre-exposure prophylaxis uptake and select implementation strategies for improving awareness, provider offering, and access.

To assess comfort receiving PrEP through different locations and delivery modes among Black men who have sex with men in Mississippi and examine associations between delivery preferences, experienced homophobia, and racism.

To determine how incomplete HIV sequence reporting affects molecular transmission-cluster detection and to assess whether network-based measures of an individual node’s expected influence could help prioritize sequence completeness and improve cluster detection.

To apply implementation mapping to identify determinants and develop, operationalize, and protocolize stakeholder-informed strategies for implementing Managed Problem Solving Plus, a community health worker-delivered intervention for HIV medication adherence and care retention, across 13 Philadelphia clinics.

To identify contextual determinants and strategies that facilitated or challenged successful integration of pre-exposure prophylaxis services across diverse United States health care settings and delivery models, using interviews guided by the Consolidated Framework for Implementation Research.

To evaluate linkage to HIV care, timing of antiretroviral treatment initiation, viral suppression, and program resource requirements after integrating rapid treatment for acute HIV infection into an existing multisite testing and linkage program in Chicago.

To describe a stepped-wedge, cluster-randomized hybrid trial protocol evaluating the effectiveness, reach, implementation cost, mechanisms, and sustainment of community health worker-delivered Managed Problem Solving Plus for HIV medication adherence and care retention across 10 Philadelphia clinics.

To explore individual, provider, and health-system factors that enable or impede PrEP uptake and persistence among young Black and Latino gay men living, working, or socializing in the Bronx in clinical and community settings.

To examine implementation challenges and organizational responses during start-up of the Bottom Up HIV care re-engagement project in New York City using the Consolidated Framework for Implementation Research and a framework distinguishing absorptive, adaptive, and transformative resilience.

To explore multidisciplinary providers’ perspectives on barriers, facilitators, implementation climate, and integration strategies for technology-based antiretroviral adherence support during pregnancy and the postpartum period in routine HIV clinical care settings.

To examine pre-exposure prophylaxis knowledge, awareness, and willingness to link to PrEP services among syringe services program clients in Miami and assess whether opioid-only versus polysubstance injection was associated with interest in PrEP linkage.

To develop and validate causal loop diagrams characterizing intersectional stigma among Black gay, bisexual, same-gender-loving, and other men who have sex with men and identify targets for improving HIV testing and prevention access.

To characterize legal and policy barriers affecting HIV prevention and care for transgender people in the Carolinas and identify community priorities and policy opportunities for advancing transgender health equity in North and South Carolina.

To characterize awareness, willingness, perceived barriers, and facilitators related to long-acting injectable antiretroviral therapy among Black sexual minority men living with HIV in the Houston and Dallas metropolitan areas of Texas.

To use rapid qualitative analysis to identify barriers, facilitators, and service innovations affecting Latinx sexual minority men’s access to HIV prevention, HIV treatment, and behavioral health services in South Florida during the COVID-19 pandemic.

To culturally adapt an evidence-based group therapy intervention for online delivery to older women living with HIV and depression and pilot its acceptability, feasibility, appropriateness, attendance, implementation barriers, and preliminary changes in depression and HIV-related quality of life.

To understand barriers and facilitators to rapid antiretroviral therapy implementation during routine clinical rollout through interviews with medical leaders from nine United States HIV clinics that were early adopters of rapid treatment.

To explore Alabama health-care providers’ knowledge, experiences, and practices regarding pre-exposure prophylaxis prescribing for Black adolescent girls and young women and to identify provider, community, health-system, and structural barriers and opportunities for improving access.

To use participatory social mapping and focus groups to characterize where young African American men who have sex with men in Jackson, Mississippi perceived HIV transmission-related behaviors to occur across geographic locations and social networks.

To estimate HIV incidence after diagnosed syphilis, gonorrhea, or chlamydia among women in King County, Washington, using 2008–2018 surveillance data and assess whether observed incidence supported national recommendations for offering pre-exposure prophylaxis after selected sexually transmitted infections.

To develop a pre-exposure prophylaxis persistence intervention with young African American men who have sex with men in Jackson, Mississippi, and conduct an open pilot assessing feasibility, acceptability, satisfaction, and participant retention over six months.

To identify barriers and facilitators to PrEP use among Black cisgender women and community health center staff in Mississippi and to select and operationalize contextually appropriate implementation strategies using implementation-science frameworks.

To identify multilevel determinants of clinic implementation of and patient demand for rapid antiretroviral treatment in Miami-Dade County and to use clinic and patient perspectives to propose implementation strategies for future testing.

To compare preferences for six community-based HIV care models versus a traditional fixed clinic among out-of-care people with HIV in the southeastern United States and to examine perceived advantages, disadvantages, and factors influencing model acceptance among patients and stakeholders.

To assess the efficacy of automated text messaging and monitoring, online peer support, and strengths-based telehealth coaching—alone and in combination—for improving uptake and adherence to pre-exposure prophylaxis, condoms, post-exposure prophylaxis, and partner reduction among at-risk young people.

To explore the workplace experiences of Black gay, bisexual, and other men who have sex with men employed in HIV prevention, treatment, community, clinical, or academic settings in Atlanta, including how intersecting identities shaped meaning, stress, burnout, and commitment.

To pilot electronic collection of patient-reported social and behavioral health information in an urban southern HIV clinic and qualitatively assess patients’ experience, comfort, perceived value, and recommendations for future use of the tablet-based tool.

To identify pediatric primary care clinicians’ preferences and concerns regarding electronic health record-based clinical decision support for recognizing adolescents who may benefit from PrEP and guiding evidence-based prescribing and follow-up.

To identify community-based HIV service organization priorities, assets, and needs related to serving sexual and gender minority clients and assess how agency services aligned with Philadelphia’s local Ending the HIV Epidemic plan.

To explore barriers and facilitators to pre-exposure prophylaxis uptake and adherence and assess attitudes toward peer navigation among young men who have sex with men at four different stages of PrEP discussion, prescribing, and adherence.

To examine preferences for daily, on-demand, injectable, and implantable PrEP and condoms among sexual and gender minority adolescents assigned male at birth and identify developmental and access factors shaping those preferences.

To explore knowledge, acceptability, concerns, and formulation preferences regarding long-acting PrEP among men who have sex with men who had initiated but discontinued daily oral PrEP at three United States clinics.

To characterize anticipated patient, health system, and structural barriers and facilitators to implementing long-acting injectable antiretroviral therapy among consumers and clinical and nonclinical stakeholders in Los Angeles County before broad clinical rollout.

To assess whether participation in a community-created trauma-informed Safety and Stabilization intervention was associated with HIV care retention, viral suppression, and post-traumatic stress symptoms among people with HIV receiving services in the southern United States.

To identify common implementation barriers, facilitators, and scalable strategies for rapid antiretroviral therapy and same-day PrEP across Ryan White-funded organizations in seven Ending the HIV Epidemic jurisdictions and service systems.

To estimate pre-exposure prophylaxis awareness and examine its relationship with sexually transmitted infections and HIV testing history among Black men who have sex with men and a history of criminal justice involvement in six United States cities.

To assess organizational readiness, clinic-level barriers, and facilitators for integrating PrEP services into Title X-funded family planning clinics across the southern United States using implementation-framework-informed survey measures and provider reports.

To evaluate multilevel determinants of pre-exposure prophylaxis adoption and implementation across three Title X family-planning clinics and to assess PrEP uptake, persistence, and adherence among female patients during six months of follow-up after clinic training and implementation planning.

To identify barriers and facilitators to integrating behavioral health and HIV care at two Ryan White-funded Atlanta clinics, with attention to young Black gay, bisexual, and other men who have sex with men.

To understand pregnant individuals’ HIV risk perceptions, PrEP knowledge and acceptability, and preferences among available or emerging PrEP formulations among patients with a recent sexually transmitted infection at an urban obstetrics clinic.

To identify characteristics associated with consistently preferring a current daily oral antiretroviral regimen over hypothetical long-acting treatment options among people with HIV participating in a discrete-choice experiment in Washington State and Atlanta, Georgia.

To assess preferences among young Black gay, bisexual, and other men who have sex with men for the degree and design of integration between HIV and mental health services at two Ryan White-funded clinics in Atlanta.

To examine patient and encounter characteristics associated with accepting an offered clinical evaluation for pre-exposure prophylaxis at the largest PrEP clinic in Mississippi using routinely documented eligibility, offer, and acceptance data from 2017 to mid-2020.

To characterize experiences of HIV stigma, pre-exposure prophylaxis stigma, stigma-management strategies, and social support among PrEP-naïve and PrEP-experienced Black cisgender women in Mississippi and explore their perceived influence on PrEP initiation and adherence.

To describe organizational practices for monitoring the PrEP care continuum and identify barriers, current supports, and expansion priorities among PrEP-providing organizations in Illinois and Missouri across the entire care continuum.

To pilot a multidisciplinary university-based HIV prevention education program for medical and pharmacy trainees and assess changes in awareness and short-term knowledge of pre-exposure prophylaxis using a five-item test administered before and after the lectures.

To examine individual- and partner-level associations between pre-exposure prophylaxis use, disclosure of PrEP use, and consistent condom use during the prior six months among Latino men who have sex with men and their sexual partners.

To elicit primary care providers’ perspectives on automated electronic health record-based HIV risk prediction models for identifying PrEP candidates, including perceived clinical benefits, implementation preferences, privacy concerns, and potential harms.

To develop and demonstrate a trauma-informed care-focused process-mapping method and use it to characterize existing trauma screening, services, workforce preparation, inclusivity, wellness, and cultural responsiveness in a southern pediatric HIV clinic serving youth aged 14–24.

To compare projections from three modeling approaches for how increases in antiretroviral treatment and pre-exposure prophylaxis uptake, separately and together, could affect new HIV infections among young Black men who have sex with men during Illinois’s 2016–2030 Getting to Zero initiative.

To use formative focus groups and interviews with men who have sex with men, transgender people who use methamphetamine, and relevant service providers to refine peer-navigation and text-message interventions and the protocol for the Hit Me Up! PrEP adherence study.

To explore health care providers’ perspectives on barriers, facilitators, and implementation strategies affecting the PrEP care continuum for Black cisgender women in the Midwestern United States using the Consolidated Framework for Implementation Research.

To explore Baltimore pre-exposure prophylaxis providers’ experiences with disruptions to PrEP promotion, initiation, and maintenance during the COVID-19 pandemic and to identify adaptations, enabling factors, and constraints affecting equitable service delivery.

To identify multilevel factors affecting HIV testing and care linkage for Latino men who have sex with men near the US-Mexico border and collaboratively tailor a feasible, acceptable peer-navigation model and its implementation strategies.

To examine how the COVID-19 pandemic disrupted PrEP access and adherence among clients of a Los Angeles health center and identify client- and staff-reported barriers despite remote-care adaptations and service modifications.

To characterize adoption, implementation experiences, perceptions, barriers, and facilitators for rapid antiretroviral therapy, rapid PrEP, and status-neutral services among Ryan White-funded clinics in selected Ending the HIV Epidemic priority areas.

To explore barriers and opportunities for HIV testing in rural Alabama through interviews with community adults and key stakeholders and to use the findings to inform implementation of a mobile HIV testing service.

To characterize communication and outreach preferences among people with HIV who were out of care in metropolitan Atlanta and explore patient, advisory-board, and peer-navigator perspectives on factors affecting acceptance of conventional contact methods and peer outreach visits.

To evaluate 48-week adherence, retention, and persistence outcomes in an open-label demonstration of daily oral tenofovir disoproxil fumarate/emtricitabine, supported by two-way text messaging and drug-level-guided counseling, among cisgender women at risk for HIV in the United States.

To document lifetime sexual behaviors related to HIV risk and use of HIV prevention services among rural adolescent sexual minority males and compare these behaviors and service-use patterns with those of urban participants in a United States online prevention program.

To characterize incomplete antibody development, later loss of test reactivity, and alternating reactive and nonreactive results by specimen and test type among Project DETECT participants initiating antiretroviral treatment and to examine associations with treatment stage.

To examine associations between unmet basic, health and social service, and economic needs and both intention to use and current use of HIV pre-exposure prophylaxis among HIV-negative Black and Latino sexual minority men aged 18–29 years in New York City.

To examine how social identity support, perceptions that peers use pre-exposure prophylaxis, and economic instability were related to PrEP engagement among men who have sex with men aged 18–25 years in a Mid-Atlantic metropolitan area of the United States.

To assess social support assets and unmet needs among underrepresented high school, undergraduate, and graduate students participating in Birmingham health sciences pathway programs using concurrent focus groups and survey data.

To identify current structural, social, behavioral, and clinical barriers and facilitators affecting pre-exposure prophylaxis use among PrEP-eligible young Black men who have sex with men and clinic staff in Mississippi.

To conduct a participatory, intersectionality-informed needs assessment of barriers to HIV care engagement in St. Louis and use findings from people with HIV, leaders, community health workers, supervisors, and frontline staff to guide intervention and implementation planning.

To identify stakeholder-perceived barriers and facilitators to delivering Managed Problem Solving through community health workers in Ryan White-funded Philadelphia clinics and organize determinants to inform implementation-strategy development in routine care.

To develop a stakeholder-driven mobile HIV clinic model for improving engagement and retention in care among people with HIV in the southern United States by eliciting service, location, confidentiality, staffing, and integration preferences.

To evaluate whether automated text messaging, online peer support, strengths-based coaching, or combinations of these approaches affected use of ancillary support and health services among sexual and gender minority youth at risk for HIV in Los Angeles and New Orleans.

To identify Philadelphia HIV testers’ perceived strengths, knowledge and competency gaps, organizational and system barriers, and willingness to adopt implementation strategies for strengthening HIV testing, sexually transmitted infection testing, pre-exposure prophylaxis recommendation, and culturally responsive prevention services.

To describe men who have sex with men’s preferences for the content, audience, tone, format, and integration of pre-exposure prophylaxis advertisements displayed within dating applications, incorporating perspectives from mobile sexual health unit users and staff.

To examine how targeted versus diverse representation in PrEP advertisements affects Black sexual minority men’s judgments, stigma, motivation, and behavior using a randomized online experiment, longitudinal follow-up, and focus groups.

To assess pre-exposure prophylaxis knowledge, attitudes, recent prescribing practices, and provider or practice characteristics associated with PrEP prescribing among Tennessee primary care clinicians using a statewide, framework-informed cross-sectional electronic survey.

To test whether a mobile iPhone game, Viral Combat, improved biologically measured adherence to pre-exposure prophylaxis over 24 weeks among a diverse sample of young men who have sex with men.

To characterize 2014–2020 trends and factors associated with awareness, provider discussion, past-year use, and current use of pre-exposure prophylaxis among English-speaking Latino sexual minority men participating in a nationwide annual online survey.

To explore HIV-negative Black sexual minority men’s responses to the written messages in pre-exposure prophylaxis visual advertisements and identify message features that could improve clarity, relevance, normalization, and acceptability in future campaigns.

To develop a high-precision natural language processing pipeline that identifies US Twitter users self-reporting as gay, bisexual, or men who have sex with men and assess how their geography and age compare with US HIV diagnosis patterns.

To quantify preferences among United States adults with HIV for treatment mode, pain, dosing interval, administration location, pretreatment requirements, and timing flexibility across hypothetical long-acting antiretroviral regimens compared with their current daily oral treatment.

To explore preferences for microeconomic intervention components that could address employment, income, housing, and food-related structural drivers of HIV vulnerability among economically vulnerable transgender women in Richmond, Virginia, and St. Louis, Missouri.

To use implementation mapping with Alabama health departments, AIDS service organizations, and community organizations to determine requirements, implementation determinants, and strategies for a statewide dashboard tracking the PrEP care continuum.

To describe determinants of community health worker integration and sustainment across three agencies serving the Memphis Transitional Grant Area and identify workforce, organizational, funding, and training strategies relevant to improving HIV care outcomes and reducing disparities.

To estimate willingness to receive PrEP screening in pharmacies and identify associated predisposing, enabling, and need-related factors among a national internet sample of cisgender sexually minoritized men in the United States.

To describe use of the Positive Peers mobile app among young people with HIV in Northeast Ohio and examine associations between self-selected app use and laboratory monitoring, care engagement, and sustained viral suppression compared with nonusers from the same clinical population.

To identify demographic and behavioral predictors of discussing PrEP and possible uptake with a medical provider among PrEP-eligible sexual and gender minority participants in a large internet-based United States cohort.

To characterize how racism, sexism, classism, and related social and structural conditions influenced deliberations about pre-exposure prophylaxis among PrEP-eligible Black cisgender women in Jackson, Mississippi, who had never received a prescription.

To rank preferences for six current and next-generation PrEP products and examine demographic and behavioral correlates of those preferences among young cisgender men who have sex with men across the United States.