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Publication Profiles

Acceptability of a Dapivirine Gel Administered Rectally to HIV-1 Seronegative Adults (MTN-033 Study)

Citation

Bauermeister JA, Tingler RC, Johnson S, et al. Acceptability of a Dapivirine Gel Administered Rectally to HIV-1 Seronegative Adults (MTN-033 Study). AIDS Educ Prev. 2021;33(5):361-376. doi:10.1521/aeap.2021.33.5.361

Implementation stage:

Pre-Implementation

Implementation outcomes reported:

Not applicable

Continuum target addressed:

Linkage to preventative care

Geography:

Non-priority jurisdiction

Study Participant Classification:

Recipients of care

Plain Language Objectives

The researchers asked 14 men in an early trial about using an experimental rectal gel through two delivery methods. They wanted to understand whether participants liked the gel and what they saw as the advantages and drawbacks of each method.

Plain Language Abstract

Researchers are developing rectal microbicide gels as possible HIV-prevention options, and people may prefer different ways of applying them. In a phase 1 trial, 14 men who have sex with men were randomly assigned in equal numbers to use 0.05% dapivirine gel with either a rectal applicator or an artificial phallus used to simulate sex. Researchers combined quantitative ratings and qualitative feedback. Eleven participants (78.6%) reported favorable gel acceptability at the end of the study, rating it the same as or more favorably than when they began. Participants identified positive features and possible improvements for both delivery methods. The results suggest value in offering more than one way to use a future gel, including options that do and do not require a conventional applicator. This small phase 1 study focused on acceptability and user experience. It did not test whether the gel prevented HIV, and the views of 14 trial participants should not be assumed to represent all men who have sex with men.

Key Takeaways

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